Systematic review of tandospirone and buspirone in treatment of patients with generalized anxiety disorder

VernacularTitle:坦度螺酮与丁螺环酮治疗广泛性焦虑症的系统评价
Author: Xiaodong FAN ; Xingxing XIE ; Chunyan ZHANG ; Wenqiang KONG ; Chunyang ZHOU ; Biao DU
Keywords: tandospirone; buspirone; generalized anxiety disorder; systematic review; meta-analysis
From: Drug Evaluation Research 2017;40(3):400-405
CountryChina
Language:Chinese
Abstract: Objective To evaluate the therapeutic effect and safety of tandospirone and buspirone in the treatment of generalized anxiety disorder.Methods The clinical control study oftandospirone and buspirone in the treatment of generalized anxiety disorder was earched by PubMed,CBM,CNKI,VIP,and Wanfang Data,with deadline from January 2000 to June 2016.Meta-analysis was carried out using RevMan5.0 software to each effect index.Results A total of seven RCTs were included involving 615 patients were identified.Meta-analysis showed that the significant efficiency rate[P=0.34,OR=1.19,95％CI (0.83～1.69)] and HAMA[P=0.80,MD=-0.08,95％CI (-0.72～0.56)] of tandospirone and buspirone had no significant difference.Two groups of adverse drug reactions,dizzy,dry,constipine,insomnia,anorexia,and nausea had no significant difference (P＞0.05).Conclusion The efficacy and adverse reaction oftandospirone and buspirone in the treatment of generalized anxiety disorder are fairly.