Preparation of andrographolide-loaded solid dispersions
10.3969/j.issn.1001-1528.2017.04.011
- VernacularTitle:穿心莲内酯固体分散体的制备
- Author:
Dongyuan SHAN
;
Ying PEI
;
Qing MENG
;
Tong LI
- Keywords:
andrographolide;
solid dispersions;
in vitro dissolution rate;
Box-Behnken method
- From:
Chinese Traditional Patent Medicine
2017;39(4):719-723
- CountryChina
- Language:Chinese
-
Abstract:
AIM To prepare the andrographolide-loaded solid dispersions.METHODS Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) were used for the analysis of solid dispersions previously prepared from the mixture of andrographolide and PVPK30 (1 ∶ 9) in autoclave.In addition to the evaluation index of in vitro dissolution rate,the influencing factors of pressure,temperature and reaction time were taken into consideration for the preparation optimization by Box-Behnken method.RESULTS Andrographolide was totally dispersed in solid dispersions in an amorphous state,manifesting an inhibited crystal diffraction peaks' formulation.Under the optimal conditions of 21.26 MPa for pressure,40.76 ℃ for temperature,and 1.13 h for reaction time,the in vitro dissolution rate was 85.49％.CONCLUSION After andrographolide is made into solid dispersions,its in vitro dissolution rate is obviously increased.
