Research progress and application outlook of paracrine functions of adipose-derived stem cells in facial anti-aging
10.3969/j.issn.2095-4344.2017.05.022
- VernacularTitle:脂肪干细胞旁分泌功能在面部抗衰老领域的研究应用与进展
- Author:
Jian GUO
;
Pijun YU
;
Luping WANG
;
Yingying SHI
;
Yi LIU
;
Wei CHEN
- From:
Chinese Journal of Tissue Engineering Research
2017;38(5):789-794
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Adipose-derived stem cel s (ADSCs) are a subset of mesenchymal stem cel s obtained from adipose tissue, which have paracrine functions, already becoming a focus in anti-aging researching. OBJECTIVE:To review the research progress and application outlook of ADSCs’ paracrine functions in facial anti-aging. METHODS:The first author searched the PubMed and CNKI databases using the keywords of“adipose-derived stem cel s, paracrine, anti-aging”in English and Chinese, respectively, to retrieve relevant articles published from January 2001 to May 2016. Repetitive articles or those with no originality were eliminated. Total y 176 articles were searched initial y, and 66 articles were included in result analysis. RESULTS AND CONCLUSION:ADSCs have paracrine function, which can secrete various growth factors (e.g., epidermal growth factor, transforming growth factorβ, platelet-derived growth factor, vascular endothelial growth factor, col agen and fibronectin) and inflammatory factors (e.g., interferon-γ, interleukin-lβ, interleukin-8, interleukin-9, interleukin-12, interleukin-15, interleukin-17 and tumor necrosis factor-α). These paracrine products of ADSCs have significant effects on anti-aging, such as inhibiting skin aging, whitening skin, assisting lipotransfer, promoting hair regeneration.
