Clinical observation of preventive hepatoprotective effect of traditional Chinese medicine on drug -induced liver injury induced by chemotherapy of breast cancer

VernacularTitle:中药预防性保肝对乳腺癌化疗所致药物性肝损伤的临床观察
Author: Dan LI ; Lan LAN ; Pan CHEN ; Zhuohong LI ; Baiping AN ; Chaofu ZHU
Keywords: Drug-induced liver injury; Breast neoplasms; Medicine,Chinese Traditional
From: Chinese Journal of Primary Medicine and Pharmacy 2017;24(5):698-701
CountryChina
Language:Chinese
Abstract: Objective To assess the efficacy and significance of hepatic protection by observing the incidence of liver injury in patients with chemotherapy who were treated and untreated with traditional Chinese medicine (TCM).Methods A retrospective analysis was applied to compare the changes in liver function tests and incidence rate of drug -induced liver injury between the observation group (treated with TCM)and the control group (untreated with TCM)after chemotherapy.Results The incidence rates of liver injury in the observation group and control group was 4.7%(2 /43)and 23.9%(11 /46)respectively.The difference between the two groups was statisti-cally significant(χ2 =6.611,P =0.01).The ALT,AST,TBIL,ALP between the two groups had statistically signifi-cant differences after treatment (all P <0.05).Conclusion Using TCMin hepatic protection can improve liver tests and reduce the incidence of drug -induced liver injury from chemotherapy.