Effects of kaempferol on learning and memory in rats with chronic cerebral ischemia and possible mechanisms
10.3969/j.issn.1001-1978.2017.01.008
- VernacularTitle:山奈酚对慢性脑缺血大鼠学习记忆能力的影响及机制探讨
- Author:
Jun ZHANG
;
Xiao CHENG
;
Huan YANG
;
Yinlin YANG
;
Tingkun ZHAO
;
Qi WANG
;
Yuehua WANG
;
Guanhua DU
- Keywords:
kaempferol;
vascular dementia (VD );
chronic cerebral ischemia;
chronic cerebral hypoperfu-sion(CCH);
bilateral common carotid arteries occlu-sion (2-VO );
learning and memory;
superoxide dis-mutase(SOD);
DJ-1 protein
- From:
Chinese Pharmacological Bulletin
2017;33(1):39-44
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects and possible mechanisms of kaemperol in the rats with chronic cere-bral ischemia.Methods Chronic cerebral hypoperfu-sion model was produced by permanent occlusion of bi-lateral common carotid arteries (2VO)in rats.After KAE treatment,the rats underwent Morris water maze and prehensile traction test.Neuronal morphology was observed using Nissl and HE staining.The activity of SOD and the content of MDA in brain tissue were de-termined.The DJ-1 protein expression was assayed by Western blot.Results Compared with 2VO model group,KAE significantly improved learning and memo-ry and the grasping ability.In addition,KAE signifi-cantly reduced brain tissue pathological injury induced by 2VO. Furthermore, KAE significantly increased SOD activity and enhanced antioxidant protein DJ-1 ex-pression in brain tissue.Conclusions KAE could sig-nificantly attenuate the cognitive impairment,limb bal-ance dysfunction and pathological injury in rats with chronic cerebral ischemia.The mechanism may be re-lated to improving the antioxidant system in vivo.
