Clinical application value of gene chip for detecting HPV DNA genotype in cervical lesions screening
10.3969/j.issn.1673-4130.2016.23.024
- VernacularTitle:基因芯片检测人乳头瘤病毒基因分型在宫颈病变筛查中的临床应用价值
- Author:
Lei WANG
- Keywords:
human papilloma virus;
thinprep cytologic test;
cervical lesion
- From:
International Journal of Laboratory Medicine
2016;37(23):3303-3305
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical application value of gene chip method for detecting human papilloma virus (HPV) DNA genotype .Methods A total of 372 samples of HPV genotype in the gynecological outpatients department of our hos‐pital from September to December 2015 were collected ,including 22 kinds of genotype(18 types of high risk ,4 types of low risk) , meanwhile all samples were performed thinprep cytologic test(TCT) .Results In 372 samples ,223 cases of HPV gene were detec‐ted with the detection rate of 59 .94% ,194 cases(52 .15% ) of high risk type and 194 cases(7 .80% ) of low risk type were detected ;the abnormal rate of TCT was 44 .08% (including atypical hyperplasia ,low‐grade and high‐grade lesion) ,the atypical hyperplasia was 22 .88% ,the detection rate of high‐grade lesion was 5 .10% and which of low‐grade lesion was 18 .01% .In the cervical lesions showing the lesion beyond inflammation ,multiple infection and cervical lesions had significant correlation (P<0 .05) .Conclusion HPV genotyping has higher clinical application in the cervical lesion screening ,moreover which has good correlation with the cyto‐logical change .Conducting HPV genotyping is beneficial to the early screening of cervical lesions .
