Therapeutic effect of ulinastatin and berberine on burn sepsis in rats
10.3969/j.issn.1000-4718.2016.12.025
- VernacularTitle:乌司他丁联合黄连素对烧伤脓毒症的疗效分析
- Author:
Qinghua LI
;
Yongqiang REN
;
Hongxu ZU
;
Xiaorong WANG
- Keywords:
Ulinastatin;
Berberine;
Burn sepsis;
Bacterial content
- From:Chinese Journal of Pathophysiology
2016;32(12):2272-2275
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the combination therapeutic effect of ulinastatin and berberine on burn sepsis in the rats.METHODS:The rats with burn sepsis were administrated with ulinastatin or berberine or combination therapy .The survival rate and body weight of the rats were measured .The levels of IL-6, IL-10 and TNF-αwere examined by ELISA.The morphological changes of the lung were observed by hematoxylin and eosin staining .The content of bacteria in the liver , lung and spleen tissues was detected .RESULTS:Combination of ulinastatin and berberine significantly increased the survival rate and body weight in the rats with burn sepsis .Moreover , combination therapy inhibited the elevation of IL-6 and TNF-αlev-els, whereas increased the IL-10 level.Combination therapy protected the structure of hepatic lobule , and further reduced the bacterial content in the liver , lung and spleen .CONCLUSION: Combination of ulinastatin and berberine improves the symptoms of burn sepsis by regulating the levels of IL-6, IL-10 and TNF-αand inhibiting the content of bacteria .
