Mechanism of Nuclear Factor-κB in Skeletal Muscle Atrophy during Prevention and Treatment of Exercise in Patients with Chronic Obstructive Pulmonary Disease (review)
10.3969/j.issn.1006-9771.2016.10.013
- VernacularTitle:核因子κB在运动防治慢性阻塞性肺疾病患者骨骼肌萎缩中的作用机制
- Author:
Weibing WU
;
Jingxin LIU
;
Xiaodan LIU
;
Zhenwei WANG
;
Juntao YAN
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
skeletal muscle atrophy;
exercise;
nuclear factorκB;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(10):1171-1174
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary (COPD) has significant extra pulmonary effects, which could induce atrophy of peripheral skeletal muscle and respiratory muscles, and significantly influence the respiratory function and quality of life. Muscle nuclear factor (NF)-κB activation plays a key role in the skeletal muscle atrophy. This article discussed the potential mechanisms on how NF-κB signaling pathway increasing protein breakdown and reducing muscle regeneration. On this basis, we explored the role of NF-κB in skeletal muscle at-rophy in patients with COPD during exercise.
