Prediction of gestational diabetes mellitus in first trimester with body mass index, fasting blood glucose and glycosylated hemoglobin combined tests
10.3969/j.issn.1006-5725.2016.19.002
- VernacularTitle:孕早期体质指数、空腹血糖和糖化血红蛋白联合检测预测妊娠期糖尿病的价值
- Author:
Liwei CEN
- Publication Type:Journal Article
- Keywords:
Gestational diabetes mellitus;
Body mass index;
Fasting blood glucose;
Glycosylated hemoglobin
- From:
The Journal of Practical Medicine
2016;32(19):3120-3122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical value of body mass index (BMI), fasting blood glucose (FPG)and glycosylated hemoglobin (HbA1c) combined tests for prediction of gestational diabetes mellitus (GDM) in first trimester. Methods 138 cases diagnosed as GDM and 133 cases of normal pregnant women were divided into study group and control group. The parameters of BMI , FPG and HbA1c were measured and compared. Results (1) BMI, FPG and HbA1c from study group were significantly higher than those from control group (P < 0.01). (2) The area under receiver operating characteristic curve (AUC) of BMI was 0.617 for predicting GDM, AUC of FPG was 0.700, and AUC of HbA1c was 0.684. When taking two of the optimal diagnostic cut-off values of BMI > 23.25, FPG > 4.25 L, HbA1c > 4.95% as screening method, AUC was 0.773. This method showed a diagnostic sensitivity of 73.3% and specificity of 82.4%. Conclusion BMI, FPG and HbA1c combined method in first trimester is valuable in predicting GDM.
