Efficacy of Berberine Hydrochloride Tablet in the Treatment of Non-alcoholic Fatty Liver Disease:A Me-ta-analysis
10.6039/j.issn.1001-0408.2015.30.20
- VernacularTitle:盐酸小檗碱片治疗非酒精性脂肪性肝病疗效的Meta分析
- Author:
Chang XU
;
Xuelong LIU
;
Jianteng NI
;
Zhen WU
;
Zhijie MA
;
Kuijun ZHAO
- Publication Type:Journal Article
- Keywords:
Berberine hydrochloride tablet;
Non-alcoholic fatty liver disease;
Efficacy;
Meta-analysis
- From:
China Pharmacy
2015;(30):4232-4235
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically review the efficacy of Berberine hydrochloride tablet in the treatment of non-alco-holic fatty liver disease(NAFLD),and provide evidence-based reference for the clinical treatment. METHODS:Retrieved from CJFD,Wanfang Database,VIP,CBM and PubMed,observational studies about Berberine hydrochloride tablet in the treatment of NAFLD were collected. After data extraction and quality evaluation,Meta-analysis was performed by using Rev Man 5.3 statistics software. RESULTS:A total of 6 studies were included,involving 294 patients. Results of Meta-analysis showed Berberine hydro-chloride tablet could significantly reduce the levels of AST[WMD=18.97,95%CI(2.25,35.70),P=0.03],ALT[WMD=31.04, 95%CI(7.17,54.91),P=0.01],TG[WMD=1.07,95%CI(0.39,1.74),P=0.002] and TC[WMD=1.31,95%CI(0.79,1.84),P<0.001] in the serum of patients with NAFLD. There were significant differences. CONCLUSIONS:Berberine hydrochloride tablet can significantly improve the liver function and blood lipid levels of patients with NAFLD,and the clinical efficacy is relatively pre-cise. Due to the limit of methodological quality,it remains to be further verified by large-scale and high quality RCT.
