The advances of the HSP90 inhibitor NVP-AUY922:applied alone or in combination with anti-tumor treatment
10.11904/j.issn.1002-3070.2015.03.021
- VernacularTitle:Hsp90抑制剂 NVP －AUY922单药及联合用药在肿瘤治疗中的研究进展
- Author:
Jiawen ZHANG
;
Jingyan CAO
;
Shi JIN
;
Yan YU
- Publication Type:Journal Article
- Keywords:
Hsp90 inhibitor;
Tumor;
TKI;
NVP-AUY922
- From:
Practical Oncology Journal
2015;(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Heat shock protein 90(Hsp90)is a highly conserved protein which have been proved to play an important role in the development and progression of malignant transformation .As one of small molecule inhibi-tors that has been detected to have potent antitumor activity in a wide range of malignancies ,NVP-AUY922 is a pyrazole scaffold drug with many advantages such as low toxicity and stable structure .As a result of this,NVP-AUY922 is extensively considered as a new promising kind of anti -tumor drug .This review intends to update the reader on advances made over the past four years in the clinical development of NVP -AUY922 in advanced cancers.
