The impact of berberine on insulin resistance and cytokines in patients with schizophrenia
10.11958/20160027
- VernacularTitle:黄连素对精神分裂症患者胰岛素抵抗与细胞因子的影响
- Author:
Jiangong LI
;
Yongping ZHAO
;
Ying LIU
;
Yuying QIU
;
Meijuan LI
;
Qiong JIA
;
Jing ZHANG
;
Jie LI
- Publication Type:Journal Article
- Keywords:
schizophrenia;
insulin;
blood glucose;
interleukin-1beta;
tumor necrosis factor-alpha;
berberine;
insulin resistance
- From:
Tianjin Medical Journal
2016;44(9):1143-1146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of berberine on serum levels of insulin resistance and cytokines in schizophrenia patients treated with risperidone. Methods Sixty-four schizophrenia patients treated with risperidone were randomized to berberine group (n=31) and control group (n=33). The fasting plasma blood glucose (FBG) and fasting insulin (Fins) were detected before and after treatment in two groups. The homeostasis model assessment for insulin resistance (HOMA-IR) was calculated. The serum levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-alpha (TNF-α) were evaluated by enzyme linked immunosorbent assay before and after the treatment. Results Compared with control group and pre-treatment group, the levels of FBG, Fins, HOMA-IR, IL-1β, IL-6 and TNF-α were significantly decreased after treatment in berberine group (P<0.05). The FBG level was significantly higher, the levels of IL-1β, IL-6 and TNF-αwere significantly lower, after treatment in control group (P < 0.01). There were no significant changes in Fins and HOMA-IR after treatment (P > 0.05). There was positive correlation between HOMA-IR and IL-1β, IL-6 and TNF-α in berberine group (r=0.316, 0.351 and 0.401, P<0.01). Conclusion Berberine can significantly decrease FBG, Fins, HOMA-IR, IL-
1β, IL-6 and TNF-α levels in schizophrenia patients treated with risperidone. The HOMA-IR level is closely correlated with IL-1β, IL-6 and TNF-αlevels.
