Effect of stress-induced hyperglycemia on myocardial perfusion and prognosis in elderly patients ;with acute myocardial infarction undergoing primary percutaneous coronary intervention
10.3760/cma.j.jssn.1673-4904.2016.09.015
- VernacularTitle:应激性高血糖与老年急诊经皮冠状动脉介入治疗术后心肌灌注及临床预后的相关性分析
- Author:
Zheng WU
;
Xiaoling ZHU
;
Wenzheng LI
;
Shiying LI
;
Hongyu PENG
;
Jian WANG
;
Donghui ZHAO
- Publication Type:Journal Article
- Keywords:
Stress disorders,traumatic;
Hyperglycemia;
Myocardial infarction;
Myocardial reperfusion
- From:
Chinese Journal of Postgraduates of Medicine
2016;39(9):816-819
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of stress-induced hyperglycemia (SHG) on myocardial perfusion and clinical prognosis in elderly patients with acute myocardial infarction (AMI) who underwent primary percutaneous coronary intervention (PCI). Methods In this study, 459 elderly patients with first-time occurrence of acute ST-elevation myocardial infarction (STEMI) who underwent primary PCI within 12 h from January 2012 to January 2015 were enrolled and followed up. All patients were divided into three groups according to serum glucose (SG) on admission: normal group (SG<7.0 mmol/L, 148 patients), SG elevation group (SG 7.0-11.1 mmol/L, 169 patients) and SHG group (SG>11.1 mmol/L, 142 patients). Myocardial perfusion indexes, including ST segment resolution (STR), TIMI myocardial perfusion grade (TMPG), peak value of creatine kinase (CK)-MB, left ventricular ejection (LVEF), and major adverse cardiac events (MACE) of patients in three groups were measured and compared after emergency PCI. Results The blood glucose levels were increased, ST-elevation 2 h after PCI were well declined, the percentages of patients with TMPG 2-3 were decreased and peak values of CK-MB were increased in the three groups (P<0.05). After 12 months of follow-up, Kaplan-Meier survival analysis showed that cumulative non-events survival rates in three groups had significantly different: 89.2% (132/148) vs. 85.8% (145/169) and 76.1% (108/142), P<0.05. Multivariate Cox regression analysis showed that SHG was the independent predictor for the occurrence of MACE in patients undergoing PCI after adjusting for age and gender (P<0.05). Conclusions SHG in elderly patients with STEMI can decrease myocardial perfusion level after primary PCI, which will lead to high incidence of MACE.
