Efficacy of solifenacin in the treatment of bladder spasm after surgical operation of chlidren hypospadias
10.3760/cma.j.issn.1000-6702.2016.06.015
- VernacularTitle:索利那新治疗小儿尿道下裂术后膀胱痉挛的疗效分析
- Author:
Lihua GUO
;
Qian ZHANG
;
Yingzhong FAN
;
Jiaxiang WANG
- Publication Type:Journal Article
- Keywords:
Solifenacin;
Children;
Bladder spasm;
Overactive bladder
- From:
Chinese Journal of Urology
2016;37(6):454-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of solifenacin in the treatment of bladder spasm after surgical operation of chlidren hypospadias.Methods From January 2014 to May 2015,60 cases of children more than 4 years old after surgical operation of hypospadias who had symptom of bladder spasm on the day of surgery were assigned into the study group (n =30) and control group (n =30),based on simple randomization.On the first day,the frequency of spasm,the duration of spasm and the incidence of urine extravasation were recorded regarded as the first day condition of bladder spasm.Patients in the study group were treated with solifenacin (5 mg once daily) for a nine days period from l th day postoperation.Patients in the control group were not treated with solifenacin.The frequency of spasm,the duration of spasm and the incidence of urine extravasation of the two groups were recorded and compared on the 3th and 9th day.Adverse events with solifenacin of two groups were recorded.The function of liver and kidney in the study group were recorded and compared.Results There were statistically significant differences(P ＜0.01) in favor of the study group over the control group in the aspect of the frequency of spasm,the duration of spasm and the incidence of urine extravasation on the 3th and 9th day.In the study group,the data compared among l th,3th and 9th was statistically significantly different,opposite to the control group.There was no statistically significant difference between the liver and kidney function of preoperation and the 9th day in the study group.The frequency of adverse events between two groups had no statistically significant difference.Conclusions Solifenacin is effective and safe in the treatment of bladder spasm after surgical operation of chlidren hypospadias
