Research progress of the relationship between klotho protein and chronic kidney disease
10.3760/cma.j.issn.1008-1372.2016.05.048
- VernacularTitle:Klotho蛋白与慢性肾脏病关系的研究进展
- Author:
Xiaoyan HOU
- Publication Type:Journal Article
- Keywords:
Glucuronidase;
Kidney diseases;
Review
- From:
Journal of Chinese Physician
2016;18(5):782-785
- CountryChina
- Language:Chinese
-
Abstract:
Klotho gene is closely related to the aging,which plays an important role in modulation of mineral metabolism,anti-apoptosis,anti-oxidation and antisenescence,etc.Klotho deficiency leads to a syndrome resembling aging,such as shortened life span,atherosclerosis,skin atrophy,hyperphosphatemia,etc.This performance is similar to that of the patients with chronic kidney disease (CKD).The levels of klotho expression and transcription are down-regulated in CKD resulted from various causes.Thus,CKD may be viewed as a state of accelerated aging and/or an age-related disease associated with Klotho deficiency.This article reviewed the relationship between Klotho and CKD.
