Efficacy observation of zolpidem in improvement of sleep quality of patients received methadone maintenance treatment

VernacularTitle:唑吡坦改善美沙酮维持治疗患者睡眠质量的疗效观察
Author: Jiangen SHEN ; Yong LIN
Publication Type:Journal Article
Keywords: Zolpidem; Methadone maintenance treatment (MMT); Sleep quality; Efficacy
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(13):2052-2054
CountryChina
Language:Chinese
Abstract: Objective To explore the efficacy of zolpidem in improvement of sleep quality of patients received methadone maintenance treatment (MMT).Methods 80 cases of MMT with insomnia were randomly divided into the study group (administered with zolpidem)and the control group (administered with placebo), 40 cases in each group.Pittsburgh sleep quality index (PSQI)and treatment emergent symptoms scale (TESS)were assessed before treatment and at the weekend of 4th,8th after treatment.Results The scores of PSQI in the study group were much lower than those in the control group (t =-2.517,P =0.014;t =-3.611,P =0.000),while the effective rate in the study group was significantly higher than that in the control group (χ2 =4.949,P =0.026). Conclusion Zolpidem could improve the sleep quality of patients with MMT.