Effects of ginkgo biloba tablets plus combined with routine therapy on HPA axis in patients with steroid-dependent asthma
10.3969/j.issn.1000-484X.2016.01.021
- VernacularTitle:银杏叶片联合常规疗法对激素依赖型哮喘患者HPA轴的影响
- Author:
Jiahui ZHENG
;
Guoshi WAN
;
Yuanxiu ZHENG
;
Fangfang HUANG
;
Zhumei WANG
- Publication Type:Journal Article
- Keywords:
Ginkgo biloba tablets;
Asthma;
HPA axis
- From:
Chinese Journal of Immunology
2016;(1):97-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of ginkgo biloba tablets plus relevant mechanism on HPA axis in patients with steroid-dependent asthma.Methods:80 patients with steroid-dependent asthma were divided into control group and experimental group at random,40 cases in every group.The control group were treated with pulmicort respules(1 mg/d) ,patients in the experiment group were given ginkgo biloba tablets in addition to routine treatment(120 mg/d).The therapeutic courses were both 12 weeks.The effective rate of reducing hormone,lung function,the plasma concentrations of ACTH and COR and the levels of PBMC GCR were deter mined before and after treatment.Results:The effective rate of reducing hormone was 89.47%in experimental group,which was 66.67%in control group.There were significant difference at the tows groups(P<0.01).There were no significant difference at lung function,the plasma concentrations of ACTH and COR and the levels of PBMC GCR at pre-treatment( P>0.05).After treatment,the lung function, the levels of plasma concentrations of COR and the levels of PBMC GCR were increased significantly than control group( P<0.01,P<0.05),the levels of plasma concentrations of ACTH was decreased significantly than control group(P<0.01).There was a significant positive correlation between the value of FEV1/FVC and the plasma concentrations of COR,the levels of PBMC GCR( r=0.724,0.632, P<0.01).There was a significant negaitive correlation between the value of FEV1/FVC and the plasma concentrations of ACTH( r=-0.668,P<0.01).Conclusion:Ginkgo biloba tablets combined with routine treatment therapy can increase the effective rate of reducing hormone in patients with steroid-dependent asthma,which can improve the lung function maybe by regulate the HPA axis and upgrade the levels of GCR.
