Effect of Early Acupuncture at Huatuo Jiajipoints on Striatalβ-endorphin and Dynorphin Levels in MCAO Rats
10.13460/j.issn.1005-0957.2016.05.0579
- VernacularTitle:早期针刺夹脊穴对 MCAO 大鼠脑纹状体β-内啡肽和强啡肽水平的影响
- Author:
Chunchen WANG
;
Linpeng WANG
- Publication Type:Journal Article
- Keywords:
Acupuncture therapy;
Points,Huatuo jiaji;
Spasm;
β-Endorphin;
Dynorphin;
Stroke
- From:
Shanghai Journal of Acupuncture and Moxibustion
2016;35(5):579-582
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of early acupuncture at Huatuo jiaji points on striatalβ-endorphin and dynorphin levels in rats with post-stroke limb spasm.Methods Seventy SD rats were randomized into group A (normal) of 9 rats and group B (sham operation) of 10 rats. After a model of post-stroke limb spasm was made in the remaining rats, they were randomized into groups C (model), D (acupuncture at Huatuo jiaji points) and E (baclofen). Group D received acupuncture at Huatuo jiaji points and group E, an oral gavage of baclofen tablets. After seven days of treatment, striatalβ-endorphin and dynorphin levels were neasured by radioimmunoassay.Resultsβ-endorphin levels increased significantly in groups C, D and E compared with groups A and B (P<0.01) and also in groups D and E compared with group C (P<0.01,P<0.05). There was no statistically significant difference inβ-endorphin levels between groups D AND E (P>0.05). Dynorphin levels increased significantly in groups C, D and E compared with groups A and B (P<0.05,P<0.01). There was no statistically significant difference in dynorphin levels between groups D and E (P>0.05).Conclusions Acupuncture at Huatuo jiaji points can increase striatalβ-endorphin levels but not change striatal dynorphin levels, which conforms to the relationship between enkephalin and spasm, and improve the animal’s spasticity.
