Immunosenescence and its role in cancer
10.3760/cma.j.issn.1673-422X.2016.02.012
- VernacularTitle:免疫衰老及其在肿瘤中的作用
- Author:
Jianhui TIAN
;
Bin LUO
;
Jiaxiang LIU
- Publication Type:Journal Article
- Keywords:
Immunity;
Aging;
Neoplasms;
Immunity,natural;
Immunity,maternally-acquired;
Tumor escape
- From:
Journal of International Oncology
2016;43(2):122-125
- CountryChina
- Language:Chinese
-
Abstract:
Immunosenescence is a biological process featured by the structural and functional decline of immunity in ageing people,which favors the carcinogenesis by rendering the body's immune surveillance and tumor escape.Decreasing clearance of tumor cells by macrophages and natural killer cell reflects the immunosenescence of innate immune,also,the tumor antigen presentation ability of dendritic cell is decreased.While,the decline of the CD8 + T cells cytotoxic effect and the secretion of tumor growth factor accounts for the immunosenescence of adaptive immunity.Intervention of immunosenescence may produce the novelty ideas of prevention and treatment of cancer.
