Eph/ephrin signaling pathway and the research progress of its mechanism in adult neurogenesis after cerebral injury

VernacularTitle:Eph/ephrin信号通路及在成年脑损伤后神经发生中的机制
Author: Jianping WANG ; Zhengfang LU ; Lie YU ; Xiaojie FU
Publication Type:Journal Article
Keywords: Eph; ephrin; Cerebral injury; Neurogenesis
From: Chinese Journal of Behavioral Medicine and Brain Science 2015;24(11):1053-1056
CountryChina
Language:Chinese
Abstract: Objective Recent researches indicate that Eph/ephrin signaling pathway is possibly related to adult neurogenesis after cerebral injury..With brief introduction of their structures and interactions,the review focus on their possible mechanism in adult neurogenesis.Methods The literatures between 2010 and 2015 were retrieved following online databases:PUBMED,ScienceDirect,Wanfang and CNKI database.The key words used in the reasearch were Eph,ephrin,cerebral injury,adult neurogenesisand so on.Results Totally 42 related articles were enrolled.And these papers discribed how researchers performed their experiments and further explained Eph/ephrin 's vital roles in adult neurogenesis.Conclusion Eph/ephrin signaling can influence adult neurogenesis after cerebral injury.positively or negatively.And Akt may be a downstream signaling molecule of Eph/ephrin that change the progress of adult neurogenesis.However,the detailed mechanisms remain to be further study.