Effect of Wheel Running on Neurogenesis in Subventricular Zone of Adult Rats post Cerebral Ischemia
10.3969/j.issn.1006-9771.2016.01.002
- VernacularTitle:运动训练对脑梗死大鼠室管膜下区神经新生的影响
- Author:
Jie FANG
;
Xiquan HU
- Publication Type:Journal Article
- Keywords:
cerebral infarction;
exercise;
neurogenesis;
rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(1):8-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of wheel running exercise on subventricular zone neurogenesis and the neural function in rats post cerebral ischemia. Methods 48 adult male Sprague-Dawley rats were induced cortical infarcts with left middle artery occlusion and were housed in either standard (control group, n=24) or wheel running (exercise group, n=24). They were assessed with neurological severi-ty scores (NSS), and the expression of Ki67 was determined with immunofluorescence, 3, 7, 14 and 21 days after training. Results Com-pared with the control group, the number of Ki67-labeled cells in subventricular significantly increased in the exercise group 14 and 21 days after ischemia (P<0.05), and the NSS decreased since 7 days after ischemia (P<0.05). Conclusion Wheel running may promote the neuro-genesis in subventricular of adult rats after cerebral infarction, which may associate with the recovery of neural function.
