Neuroprotective activities of isorhynchophylline on Alzheimer′s disease and other central nervous systems
10.16571/j.cnki.1008-8199.2015.10.024
- VernacularTitle:异钩藤碱对阿尔茨海默病及其他中枢神经系统疾病的药理作用研究进展
- Author:
Xiaojin LUO
- Publication Type:Journal Article
- Keywords:
Isorhynchophylline;
Alzheimer′s disease;
Central nervous system;
Pharmacological effects
- From:
Journal of Medical Postgraduates
2015;28(10):1112-1115
- CountryChina
- Language:Chinese
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Abstract:
Isorhynchophylline ( IRN) is an alkaloid isolated from Uncaria rhynchophylla .IRN mainly acts on cardiovascular and central nervous systems diseases including hypertension , brachycardia and sedation .In recent years , it has been found that IRN has widespread pharmacological effects in central nervous disease .This review aim at reviewing neuroprotective activities of Isorhynchophyl-line on Alzheimer′s disease and other central nervous systems diseases via improving learning and memory impairments , inhibiting Tau protein hyperphosphorylation , antagonizing β-Amyloid-iInduced neurotoxicity , and reducing glia-secretory inflammatory factors .
