Correlation between soluble receptor for advanced glycation endproducts and arterial stiffness in patients with metabolic syndrome
10.3760/cma.j.issn.1671-0282.2015.08.016
- VernacularTitle:代谢综合征患者可溶性晚期糖基化终产物受体与动脉僵硬度的关系
- Author:
Chaowei TIAN
;
Li WANG
;
Rong JIN
;
Yun ZHONG
;
Shiming LIU
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Diabetes mellitus;
Soluble receptor for advanced glycation endproducts;
Pulse wave velocity;
Arterial stiffness;
Atherosclerosis;
High density lipoprotein cholesterol;
Insulin resistance
- From:Chinese Journal of Emergency Medicine
2015;24(8):882-886
- CountryChina
- Language:Chinese
-
Abstract:
Objective investigate the correlation between plasma soluble receptor for advanced glycation endproducts (sRAGE) and arterial stiffness in patients with different types of metabolic syndrome (MS).Methods A total of 180 subjects were drawn from a epidemiologic follow-up study,including 60 cases non-metabolic syndrome (NMS),60 cases metabolic syndrome without diabetes mellitus (NDMMS),60 cases metabolic syndrome with diabetes mellitus (DMMS).Carotid femoral arterial pulse wave velocity (CFPWV) was assessed by the French KangPuLe atherosclerosis measurement instrument,and plasma sRAGE levels were measured by ELISA.Comparison of mean in multiple groups was conducted by analysis of variance.Multivariate analysis was done with multiple linear stepwise regression analysis.P ＜ 0.05 was considered as statistically significant difference.Results Compared with NMS group,plasma sRAGE levels were significantly lower in DMMS and NDMMS groups [(635.07 ± 229.20) pg/mL vs.(671.17 ± 358.16) pg/mL vs.(992.99 ± 427.83) pg/mL,P =0.001].CFPWV of DMMS group was significantly higher than that of NMDMS and NMS groups (14.22 ±3.14) m/s vs.(12.15 ±2.79) m/s vs.(11.66 ± 2.52) m/s,P =0.002).Plasma sRAGE level was negatively correlated with CFPWV (r =-0.278,P =0.005).(3) Multiple linear regression analysis demonstrated that age (β =-0.091,95％ CI-0.096 ～-0.095,P =0.031),HDL-C (β =1.295,95％ CI 1.231 ～ 1.360,P =0.022) and sRAGE (β =0.119,95％ CI 0.118 ～ 0.130,P =0.032) had a significant effect on CFPWV.Conclusions The increased arterial stiffness is closely related to the discreased plasma sRAGE levels in MS.Plasma sRAGE maybe a novel target for vascular disease prevention and treatment in patients with metabolic syndrome.
