Neuroprotective effects of statins in subarachnoid hemorrhage
10.3760/cma.j.issn.1673-4165.2015.07.013
- VernacularTitle:他汀类药物在蛛网膜下腔出血中的神经保护作用
- Author:
Junhui CHEN
;
Yuhai WANG
- Publication Type:Journal Article
- Keywords:
Subarachnoid Hemorrhage;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Vasospasm,Intracranial;
Neuroprotective Agents
- From:International Journal of Cerebrovascular Diseases
2015;23(7):554-558
- CountryChina
- Language:Chinese
-
Abstract:
Subarachnoid hemorrhage (SAH) is a common cerebrovascular disease,its disability and mortality rates are higher.It has been confkmed that early brain injury (EBI) and cerebral vasospasm (CVS) are the major pathophysiological mechanisms of causing neurological dysfunction and death after SAH.There are a variety of factors of causing CVS and EBI,including nitric oxide,endothelin,oxyhemoglobin,and proinflarnmatory cytokines.A large number of animal experiments and clinical research have confrmed that statins have neuroprotective effects.This article reviews the neuroprotective effects and its mechanisms of statins in SAH
