Effect of SIRT1 on cell proliferation and senescence of human pancreaticβ-cells CRL-1837
10.3760/cma.j.issn.1000-6699.2015.07.016
- VernacularTitle:去乙酰化酶1对人胰腺β细胞增殖及衰老的影响
- Author:
Xiaoling TIAN
;
Dongliang ZHU
;
Fengping LIN
;
Simin ZHU
;
Guanya CHEN
;
Caiyan LI
- Publication Type:Journal Article
- Keywords:
Sirtuin;
Pancreatic β-cells;
Proliferation;
Senescence;
Tumor suppressor gene p53
- From:Chinese Journal of Endocrinology and Metabolism
2015;(7):621-622
- CountryChina
- Language:Chinese
-
Abstract:
Histone deacetylase 1 ( sirtuin 1, SIRT1) is an important member of deacetylase family, and plays an important role in the process of malignant tumor and embryonic development. In this article it was found that overexpression of SIRT1 could accelerate the DNA synthesis in human pancreatic beta cell CRL-1837 and inhibit cell senescence. SIRT1 also could bind to p53 as detected by co-immunoprecipitation and could change the phosphorylation level of p53.
