Progress in Stat3 and SirT1 gene in the pathogenesis of rheumatoid arthristis

VernacularTitle:Stat3基因和 SirT1基因参与类风湿关节炎发病机制的研究进展
Author: Zhantao DENG ; Yunlong ZHAO ; Shuo CHEN ; Jianning ZHAO
Publication Type:Journal Article
Keywords: Rheumatoid arthritis; Stat3; SirT1; Fibroblast-like synoviocytes
From: Journal of Medical Postgraduates 2015;(9):1001-1003
CountryChina
Language:Chinese
Abstract: Rheumatoid arthritis ( RA) is a chronic inflammatory disease involving progressive articular damage cause by inflam-matory cells and synoviocytes.Stat3 gene, which is confirmed to play a role in the pathogenesis of RA, regulates the metabolism and apoptosis of the fibroblast-like synoviocytes ( FLS) .SirT1 gene relating to the bone formation was indicated to play a role in the patho-genesis of RA in recent years.This review introduces the pathogenesis and targeted treatment of RA and makes a prediction about the relation between Stat3 and SirT1 gene.We hope it will provide a new direction for the research of RA.