Role of inflammation in the mechanism of the commorbidity of depression and pain
10.16571/j.cnki.1008-8199.2015.08.026
- VernacularTitle:疼痛与抑郁共病的炎症机制
- Author:
Jiamin QIN
;
Yongjing LU
;
Lun CAI
- Publication Type:Journal Article
- Keywords:
Pain;
Depression;
Inflammation
- From:
Journal of Medical Postgraduates
2015;(8):893-896
- CountryChina
- Language:Chinese
-
Abstract:
Comorbid depression and chronic pain are highly prevalent in individuals suffering from physical illness .Here, we critically examine that inflammation is the possible mechanism of comorbidity of pain and depression .These mechanisms include direct effects of cytokines on the neuronal environment or indirect effects via downregulation of G protein -coupled receptor kinase 2, activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase that generates toxic kynurenine metabolites .We review the role of in-flammation in the mechanism of the commorbidity of depression and pain .
