Research progress of mammalian target of rapamycin and hypoxia-inducible factor-1 in malignant tumors
10.3760/cma.j.issn.1006-9801.2015.06.019
- VernacularTitle:哺乳动物雷帕霉素靶蛋白、缺氧诱导因子-1在恶性肿瘤中的研究进展
- Author:
Qian WANG
;
Yanlong SHI
- Publication Type:Journal Article
- Keywords:
Tumor;
Mammalian target of rapamycin;
Hypoxia-inducible factor-1;
Targeted therapy
- From:
Cancer Research and Clinic
2015;27(6):429-432
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumor is an individual disease that caused by gene mutation and disorder of protein expression.The abnormity of mammalian target of rapamycin (mTOR) signaling pathways is closely related to the tumors,and its main biological function is the regulation of protein synthesis and vascular endothelial cell proliferation.However,the activation of mTOR can increase the expression of hypoxia-inducible factor-1 (HIF-1),maintain the acid microenvironment of tumor,promote tumor cell invasion and metastasis,and affect prognosis of tumor.At present,targeted therapy with mTOR and HIF-1 for new targets and gene therapy have become hot points.
