Research progress of microRNA in acute leukemia with molecular and cytogenetic abnormalities
10.3760/cma.j.issn.1009-9921.2014.10.017
- VernacularTitle:微小RNA在伴遗传学异常的急性白血病中的研究进展
- Author:
Miao SU
- Publication Type:Journal Article
- Keywords:
microRNA;
Leukemia,myelocytic,acute;
Leukemia,lymphoblastic,acute
- From:
Journal of Leukemia & Lymphoma
2014;23(10):632-635
- CountryChina
- Language:Chinese
-
Abstract:
microRNA (miRNA) refers to small (19-25 nt) single-stranded noncoding RNA molecules that work as post-transcriptional regulator for gene expression by binding to 3' untranslated regions of target mRNA,thus inducing its digestion,degradation and translational repression.Many studies have confirmed that dysregulation of miRNA expression can cause disruption of the hematopoietic system and contribute to leukemogenesis by regulating the expression of some oncogenes and anti-oncogenes.The unique miRNA expression profiles associated with cytogenetic aberrations and mutational status of protein-coding genes may reveal insight into the biology of these leukemia types.This review discussed the latest studies on miRNA expression in different cytogenetic and molecular subtypes of acute myelocytic leukemia and acute lymphoblastic leukemia.
