Research progress on feedback activation mechanism of mammalian target of rapamycin in tumors
10.3760/cma.j.issn.1006-9801.2014.11.020
- VernacularTitle:哺乳动物雷帕霉素靶蛋白的反馈激活机制在肿瘤中的研究进展
- Author:
Taoran YAN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Mammalian target of rapamycin;
Feedback activation mechanism
- From:
Cancer Research and Clinic
2014;26(11):785-788
- CountryChina
- Language:Chinese
-
Abstract:
As the meeting point of signaling pathways actived by growth factors and amino acids,especially leucine,in tumor cells,mammalian target of rapamycin (mTOR) plays an important role as a center factor of regulation.Recently,it was acknowledged gradually that feedback activation mechanisms of mTOR can influence the efficiency of rapamycin and its analogs in antitumor therapy.Thus,the study about feedback mechanism of mTOR and the combination therapy of mTOR inhibitors and specificd pathway inhibitors has become the hot area in cancer therapy and prevention.
