Functional mechanism of SIRT1 gene in tumor
10.3760/cma.j.issn.1673-422X.2015.01.010
- VernacularTitle:SIRT1基因在肿瘤中的作用机制
- Author:
Wei MA
;
Ying LU
;
Jun MAO
;
Wenyue ZHAO
;
Lianhong LI
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Genes,tumor suppressor;
Carcinogens;
SIRT1
- From:
Journal of International Oncology
2015;42(1):40-42
- CountryChina
- Language:Chinese
-
Abstract:
Sirtuin 1 (SIRT1),the Ⅲ class deacetylation enzyme,is a kind of NAD + dependent histone deacetylation enzyme.The role of SIRT1 in tumor has the duality.It can inhibit inflammation,tumor angiogenesis and interact with tumor related gene to inhibit tumor development.However,it can also regulate tumor related genes,and epithelial-mesenchymal transition,promote tumor cell proliferation and tolerance of radiotherapy and chemotherapy,and maintain the stemness of cancer stem cells to promote tumor proliferation,invasion and metastasis.
