Impact of hyperglycemia on hypersensitive C-reaction protein, B-type natriuretic peptide and ventricular remodeling of elder patients with acute myocardial infarction
10.3760/cma.j.issn.1008-6315.2014.11.011
- VernacularTitle:高血糖对老年急性心肌梗死患者血B型脑钠肽、超敏C反应蛋白和心室重构的影响
- Author:
Weisheng LU
;
Fang LIU
;
Jiangrong ZHANG
;
Huimin YUAN
;
Yichen WANG
- Publication Type:Journal Article
- Keywords:
Myocardial infarction,acute;
Hyperglycemia;
Elder;
Hypersensitive C-reaction protein;
B-type natriuretic peptide;
Ventricular remodeling
- From:Clinical Medicine of China
2014;30(11):1156-1158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of hyperglycemia on Hypersensitive C-reaction protein (hsCRP),B-type natriuretic peptide(BNP) and ventricular remodeling in elder patients with acute myocardial infarction(AMI).Methods One hundred and twenty elder patients with AMI are divided into hyperglycemia group(blood sugar in admission ＞ 7.8 mmol/L) and non-glycemia group(blood sugar in admission ≤7.8 mmol/L).The levels of blood sugar in admission,hsCRP,BNP were detected.LVEF,LVEDD,LVESD,WMS were observed by cardiac echo in admission and two weeks after therapy.Results The blood sugar in admission,hsCRP and BNP of the patients in hyperglycemia group were (9.6 ± 0.6) mmol/L,(1 750.6 ±677.1) ng/L,(56.1 ±38.6) ng/L,higher than those in non-glycemia group (t =38.679 and P =0.000; t =11.941 and P =0.000; t =3.288 and P ＜0.01,respectively).LVEF,LVEDD,LVESD and WMS of patients in hyperglycemia group didn't show statistical significance before and after therapy.However,there were significant in hyperglycemia group (t =2.049 and P =0.043,t =2.836 and P =0.005,t =3.814 and P =0.000,t =2.086 and P =0.039,respectively).Conclusion Hyperglycemia can reduce the increase of hsCRP and BNP,which has an impact on hsCRP,BNP and ventricular remodeling in elder patients with acute myocardial infarction,but the mechanism need to further research.
