SIRT1 in vascular related diseases:its progress
10.7644/j.issn.1674-9960.2015.06.014
- VernacularTitle:SIRT1在血管相关性疾病中的研究进展
- Author:
Zhan GAO
;
Xiaoqin HA
;
Lisheng WANG
- Publication Type:Journal Article
- Keywords:
SIRT1;
ischemic stroke;
atherosclerosis;
neoplasm;
mechanism
- From:
Military Medical Sciences
2015;(6):468-471
- CountryChina
- Language:Chinese
-
Abstract:
Silent mating type information regulation 2 homolog-1 ( SIRT1 ) is a nicotinamide adenine dinucleotide ( NAD)-dependent deacetylase, which can deacetylate histone and non-histone proteins and is involved in many life proces-ses, such as energy metabolism, cell senescence and apoptosis.SIRT1 can enhance the cellular energy supply, inhibit cell apoptosis, alleviate inflammation, enhance the resistance of oxidative stress and improve the function of endothelial cells by deacetylating relevant factors in many vascular-related diseases.This article summarizes the current research progress in the function and signal pathway of SIRT1 in ischemic stroke, atherosclerosis and tumors.
