Proto-oncogene Bmi-1 and non-small cell lung cancer
10.3760/cma.j.issn.1673-422X.2015.04.015
- VernacularTitle:原癌基因 Bmi-1与非小细胞肺癌
- Author:
Xiangli LAI
;
Guosheng FENG
- Publication Type:Journal Article
- Keywords:
Proto-oncogene;
Carcinoma,non-small-cell lung;
Bmi-1
- From:
Journal of International Oncology
2015;(4):295-297
- CountryChina
- Language:Chinese
-
Abstract:
B-cell specific moloney leukemia virus insertion site 1(Bmi-1)gene is a core member of the polycomb group genes,considered to be a proto-oncogene;Bmi-1 plays an important role in cell self-renewal, proliferation and apoptosis. Several studies have shown that Bmi-1 is highly expressed in non-small cell lung cancer;furthermore,the expression level of Bmi-1 is closely related to the occurrence,development,incursion and prognosis of non-small cell lung cancer. Bmi-1 is expected to become a novel tumor molecular marker,and provides a new direction for the treatment of non-small cell lung cancer.
