Pharmacodynamic studies on cardioprotective function of Zhurihen dripping pills in experimental animals
- VernacularTitle:朱日很滴丸对实验动物心脏保护功能的药效学研究
- Author:
Yunfeng XIAO
;
Wenyan LI
;
Shuang LIU
;
Sibo XING
;
Jingkun LU
;
Shengsang NA
- Publication Type:Journal Article
- Keywords:
Zhurihen dripping pills;
experimental animals;
cardioprotective
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;37(4):24-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the cardioprotective function of Zhurihen dripping pills in experimental animals.Methods By hypoxia tolerance model and isoproterenol hydrochloride induced acute hypoxia model, measuring the time of death in mice.For rat serum LDH, CK, SOD and MDA were measured to observe protective effect of Zhurihen dripping pills on vasopressin-induced acute myocardial ischemia model.The effect of Zhurihen dripping pills on latency and durations were observed in acute arrhythmia induced by inhaled chloroform – epinephrine rabbits model.Results The hypoxia tolerance in mice and myocardial hypoxia tolerance significantly improved by Zhurihen dripping pill, and prolonged the survival time in mice.The serum level of LDH, CK, SOD and MDA significantly improved, and protected the impaired myocardial cell in rats.The latent period of arrhythmia was significantly prolonged and duration of arrhythmia was shortened in rabbits.Conclusion Zhurihen dropping pills an improve myocardial oxygen deficiency, anti-arrhythmia effect and protect myocardial cells.
