The clinical significance of the detection of serum hs -CRP and interleukin -17 in senium type 2 diabetes with macroangiopathy
10.3760/cma.j.issn.1008-6706.2015.11.002
- VernacularTitle:老年2型糖尿病大血管病变患者血清超敏C反应蛋白及白细胞介素17检测的临床意义
- Author:
Rui LI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Diabetic Angiopathies;
Interleukin -17;
C -Reactive Protein;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(11):1606-1608
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum hs -CRP,IL -17 levels and senium type 2 diabetic macrovascular complications and its clinical significance.Methods The serum levels of hs -CRP and IL-17 were measured with immunoturbidimetry and ELISA respectively in 80 cases of type 2 diabetic patients with macrovascular complications,80 cases of the absence of any major vascular complications in patients with type 2 diabetes and 80 healthy subjects as the control.Results The serum hs -CRP and IL -17 levels of senium type 2 diabetic Patients with macrovascular complications were significantly higher than those of patients without macrovascular complication and healthy control group(t =19.18,23.14,all P <0.01);And serum hs -CRP and IL -17 levels of seniumtype 2 diabetic patients without macrovascular complications were also significantly higher than those of the healthy control group (t =23.64,19.97,all P <0.05 );While serum hs -CRP and IL -17 levels in different subgroup of type 2 diabetic patients with macrovascular complications were no significantly statistical significance(F =1.08,1.49,all P >0.05);In patients of type 2 diabetic Patients with macrovascular complications,hs -CRP was positively correlated with serum IL -17(r =0.712,P <0.05).Conclusion Hs -CRP and IL -17might be involved in the process of inflammatory response to diabetic macroangiopathy,and may have important role in the pathogenesis of senium type 2 diabetic patients with macrovascular complications.Detemination of hs -CRP and IL -17 levels in type 2 diabetic patients may be useful for early detecting diabetic macrovascular complications and serve as the index in monitoring the state of diabetic macrovascular complications.
