Research progress in aberrant sphingolipid metabolism and obesity and obesity-mediated insulin resistance
- VernacularTitle:鞘脂代谢异常与肥胖相关的胰岛素抵抗研究进展
- Author:
Yujie ZHUO
;
Guang YANG
- Publication Type:Journal Article
- Keywords:
Sphingolipid;
Ceramide;
Obesity;
Insulin resistance
- From:
Journal of Medical Postgraduates
2015;(3):329-332
- CountryChina
- Language:Chinese
-
Abstract:
Sphingolipids are essential components of cellular membrane , regulating important physiologic function of cells .Al-terations of sphingolipid metabolism are closely related to the pathogenesis of several chronic diseases .Ceramide biogenesis , the center of sphingolipid metabolism , includes de novo ceramide synthesis , ceramide formation via breakdown of complicated sphingolipids and so on . Recent studies found that aberrant sphingolipid metabolism is strongly linked to insulin resistance associated with obesity .The review fo-cuses on recent advances about aberrant sphingolipid metabolism in the pathogenesis of insulin resistance associated with obesity .
