Therapeutic efficacy of artemether 300 mg - diluted powder formulation (Erapas) product of Vietnam for treatment of uncomplicated P.falciparum malaria
- Author:
Nong Thi Tien
- Publication Type:Journal Article
- Keywords:
malaria, P.falciparum, artemether
- MeSH:
malaria;
Malaria, Falciparum;
Therapeutics;
Artemisinins
- From:Journal of Malaria and parasite diseases Control
2003;0(1):51-56
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The clinical studies were carried-out in the commune Health Center of Quang Tri and Ninh Thuan provinces from June to December, 2003. Recrudescence and re-infection analysises by PCR method were performed at NIMPE`s laboratory. The efficacy of Erapas was evaluated for uncomplicated P.falciparum malaria with 5-day regimens (4mg/kg on the first day, followed by 2mg/kg once a day for 4 days). 109 patients were gathered in a group of Erapas treatment. Of which, 102 patients were followed-up to Day 28. Blood sample PCR analysises of 2 patients having parasite re-appearance at day 21 showed that both 2 cases were P.falciparum re-infection. The median (range) fever clearance time was 1.3 (1-2) day(s). The median (range) parasite clearance time was 2.5 (1-3) day(s). The research results showed that the cure rate by the 28¬th day was 100%. Erapas has high effectiveness for treament of uncomplicates faciparum malaria with high tolerance
