Effects of corticotropin releasing factor on dendritic development of hippocampal neurons

VernacularTitle:促肾上腺皮质激素释放因子对海马神经元树突生长发育的影响
Author: Zhijuan GE ; Xiaoyun MA ; Jianquan ZHENG
Publication Type:Journal Article
Keywords: stress; corticotropin releasing factor; corticotropin releasing factor receptor; hippocampal neurons; dendrite
From:Journal of International Pharmaceutical Research 2014;(6):653-657
CountryChina
Language:Chinese
Abstract: Stress exerts profound effects on cognitive and emotional functions. As a regulator of response to stress,the corticotropin releasing factor (CRF) during stress impacts organism function through hypothalamic-pituitary-adrenal axis. Recent research has shown that dendritic branches were abnormal and dendritic spine was lost under stress. In contrast,stressed mice with CRF receptor 1 (CRFR1) deficiency or CRFR1 antagonist exhibited normal dendritic morphology of hippocampal neurons .The structure and related factors expression of hippocampal neurons were affected by CRFR1 as a G protein-coupled receptor(GPCR), but the molecular mechanism about CRF-induced direct injury effect on hippocampal neurons has been poorly understood. The paper reviews the research progress on the contribution of stress activated CRF-CRF receptor signaling to the structure and related factors of hippocampal neurons.