EGCG ameliorating learning and memory impairment in APP/PS1 mice by inhibiting p75 NTR pathway
10.3969/j.issn.1001-1978.2014.10.019
- VernacularTitle:EGCG通过抑制p75 NTR通路对APP/PS1小鼠学习记忆障碍的改善作用
- Author:
Shilun YANG
;
Mingyan LIU
;
Xin ZHONG
;
Ke DU
;
Weifan YAO
;
Haishan ZHAO
;
Minjie WEI
- Publication Type:Journal Article
- Keywords:
EGCG;
NGF;
p75NTR signaling;
Alzhei-mer′s disease;
APP/PS1 transgenic mice;
learning and memory impairment
- From:
Chinese Pharmacological Bulletin
2014;(10):1419-1424
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate whether EGCG treat-ment ameliorates cognitive deficits in APP/PS1 trans-genic mice and, whether it has the ameliorating effect of p75 NTR signaling to neuronal apoptosis in the hippo-campus of APP/PS1 mice. Methods Morris water maze test and locomotivity test were used to predict be-havioral changes; further TUNEL staining and Fluoro-Jade B staining were applied to confirm the neuronal apoptosis and neuronal degeneration;Western blot was employed to detect protein expression levels of p75 NTR signaling in the hippocampus of APP/PS1 mice. Re-sults EGCG treatment dramatically ameliorated the cognitive impairments, and inhibited the neuronal ap-optosis in the APP/PS1 mice. Moreover, EGCG treat-ment dramatically inhibited the p75 NTR signaling by de-creasing the p75ICD expression, JNK2 phosphorylation, and cleaved-caspase 3 expression. Conclusion EGCG treatment dramatically ameliorates the cognitive impairments, and inhibits the neuronal apoptosis by in-hibiting the p75NTR signaling.
