Determination of Organophosphate Esters in Cosmetics by Stable Isotope Dilution-Gas Chromatography-Mass Spectrometry
10.11895/j.issn.0253-3820.140383
- VernacularTitle:稳定同位素稀释气相色谱-质谱联用测定化妆品中5种磷酸三酯类化合物
- Author:
Wanqing HAN
;
Haiying LUO
;
Liwei CHEN
;
Yuluan WU
;
Yanping XIAN
;
Bin WANG
- Publication Type:Journal Article
- Keywords:
Organophosphate ester;
Stable isotope-labeled internal standard;
Cosmetic;
Gas chromatography-mass spectrometry
- From:Chinese Journal of Analytical Chemistry
2014;(10):1441-1446
- CountryChina
- Language:Chinese
-
Abstract:
A method based on stable isotope dilution gas chromatography-mass spectrometry ( GC-MS ) was established to determine five kinds of organophosphate esters ( OPEs ) in different kinds of cosmetics. For cream and wax-based cosmetics, samples were extracted by appropriate solvent, and then purified by ENVI-Carb solid phase extracting column. For powder and aqueous samples, GC-MS test could be operated directly after solvent extraction and concentration. All of the samples were separated by DB-5MS (30 m×0. 25 mm× 0. 25 μm) chromatographic column, and detected by selected ion monitoring ( SIM ) mode. The target analytes were qualitatively confirmed by retention time and abundance ratio of characteristic ions, and quantified by stable isotope diluted internal standard method. Under the optimized conditions, the linear coefficients of the OPEs were larger than 0. 9995, the detection limits were 1. 0-30 μg/kg, the average recoveries ( n=6 ) ranged from 89 . 5% to 105%, and the RSDs were in the range of 2 . 9%-9 . 1%. The developed method, which was characteristic by satisfactory purification effect, favorable matrix effect elimination capacity, as well as high recovery, was suitable for the determination of OPEs in different kinds of cosmetic matrices.
