Research progress on SIRT1-FoxO-autophagy pathway
10.3969/j.issn.1001-1978.2014.07.004
- VernacularTitle:SIRT1-FoxO-自噬通路研究进展
- Author:
Jun XU
;
Xiulan HUANG
- Publication Type:Journal Article
- Keywords:
Autophagy;
FoxO;
SIRT1;
Deacetylate;
Diseases;
Pathway
- From:
Chinese Pharmacological Bulletin
2014;(7):901-904
- CountryChina
- Language:Chinese
-
Abstract:
FoxO as an important transcription factors,can be deacetylated by SIRT1 (a sort of deacetylases),SIRT1-FoxO-au-tophagy pathway is likely to play a vital role in some diseases,e. g.diabetes,aging,obesity,cancer,cardiovascular diseases and muscle atrophy,etcetera.This paper aims to analy transcription-al regulation mechanism of FoxO,and reviews the progress of SIRT1-FoxO-autophagy pathway.
