Effects of berberine on neurological effect and inflammatory factor in diabetes rats
- VernacularTitle:黄连素对糖尿病大鼠神经功能和炎症因子的影响
- Author:
Jinzu LING
;
Longrui PAN
- Publication Type:Journal Article
- Keywords:
Berberine;
Diabetic peripheral neuropathy;
Interleuk-1β;
Tumor necrosis factor-α;
High-sensitivity C -reactive protein
- From:
Journal of Chinese Physician
2010;(z1):33-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of berberine on interleuk-1β( IL-1β) and tumor necrosis factor-α( TNF-α) and high-sensitivity C-reactive protein ( hs-CRP ) in diabetes rats induced by Streptozotocin ( STZ) , to explore the possible mechanisms of berberine on diabetic peripheral neuropathy . Methods Adult male SD rats were randomly divided into 4 groups:normal group , diabetic peripheral neu-ropathy group, berberine (100 mg/kg) group, berberine (187.5 mg/kg) group.The diabetic rat modes were i.p.injected with 1%STZ for two weeks, the rats were treated for 8 weeks respectively with berber-ine.The contents of IL-1βand TNF-αand hs-CRP in the serum and sciatic nerve were determined respec-tively by ELISA .Results The concentration of IL-1βand TNF-αand hs-CRP dropped obviously compared to DPN group ( P <0.05 ) .Conclusion It is suggested that berberine could possess the functions of de-creasing inflammatory mediator , antagonizing inflammatory reaction .Its therapeutic mechanism might be correlated with the improvement of inflammatory condition of diabetic rats ,and the promotion of sensitivity of insulin signal transduction in target tissues .
