Effect of chemotherapy on sedation with propofol in breast cancer patients
10.3760/cma.j.issn.0254-1416.2014.04.004
- VernacularTitle:化疗因素对乳腺癌患者异丙酚镇静效应的影响
- Author:
Juntao TAN
;
Hongmeng XU
;
Li JIA
;
Yuying XING
;
Yong WANG
;
Dongjie QIU
- Publication Type:Journal Article
- Keywords:
Drug therapy;
Propofol;
Conscious sedation;
Dose-response relationship,drug
- From:Chinese Journal of Anesthesiology
2014;34(4):395-397
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of chemotherapy on sedation with propofol in breast cancer patients.Methods One hundred female patients,of ASA physical status Ⅰ or Ⅱ,aged 20-60 yr,scheduled for elective modified radical mastectomy,were divided into 2 groups (n =50 each) according to whether receiving neoadjuvant chemotherapy before operation:non-chemotherapy group (group Ⅰ) and neoadjuvant chemotherapy group (group Ⅱ).The breast cancer patients received operation directly in group Ⅰ.The breast cancer patients received neoadjuvant chemotherapy in group Ⅱ.Epirubicin 75-100 mg/m2 was injected intravenously on 1st and 2nd days,docetaxel 75 mg/m2 was injected intravenously on 3rd day,and 3 weeks were considered as 1 course of treatment.The patients received operation at 3 weeks after the end of 4 courses of treatment in group 1.Anesthesia was induced with propofol given by target-controlled infusion and the target plasma concentration of propofol was 3.5 μg/ml.The time for loss of consciousness and consumption of propofol at loss of consciousness were recorded.Results Compared with group Ⅰ,the time for loss of consciousness was significantly shortened,and the consumption of propofol at loss of consciousness and BIS value were decreased in group Ⅱ.Conclusion Chemotherapy can enhance propofol-induced sedation and promote the onset of propofol in breast cancer patients.
