Expression of Bmi-1 and p16 gene in transitional cell carcinoma of bladder
10.3760/cma.j.issn.1673-4904.2014.11.002
- VernacularTitle:Bmi-1和p16基因在膀胱移行细胞癌中的表达及临床意义
- Author:
Qingsong ZHAO
;
Ye LIU
;
Zhanpeng LU
;
Duangai WEN
;
Jun HE
- Publication Type:Journal Article
- Keywords:
Genes,p16;
Gene expression;
Urinary bladder neoplasms;
Bmi-1
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(11):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of Bmi-1 and p16 gene in transitional cell carcinoma of bladder(TCC) tissue and explore its clinical significance.Methods The expression of Bmi-1 and p16 gene were detected by real-time quantitative polymerase chain reaction in 61 cases of TCC tissue and 12 cases of normal bladder tissue.Results The expression of Bmi-1 gene in TCC tissue was significantly higher than that in normal bladder tissue (0.242 ± 0.129 vs.0.031 ± 0.011),and the expression of p16 gene was significantly lower than that in normal bladder tissue (0.059 ± 0.021 vs.0.165 ± 0.029),there was significant difference (P ＜ 0.05).The expression of Bmi-1 and p16 gene were highly correlated with pathological grades,clinical stages and tumor recurrence (P ＜ 0.05 or ＜ 0.01).But there were not correlated with age and gender (P ＞ 0.05).There was a negative correlation between the expression of Bmi-1 gene and p16 gene in TCC tissue(rs =-0.714,P＜ 0.05).Conclusions Bmi-1 gene high expression and p16 gene low expression may be involved in the occurrence and development process of TCC.Bmi-1 may decrease the expression of p 16 gene in some ways,and then lead to the occurrence and development of TCC.
