Tryptophan hydroxylase 2 gene polymorphisms and poststroke anxiety disorders

VernacularTitle:色氨酸羟化酶2基因多态性与脑卒中后焦虑的关系
Author: Chunxia WANG ; Jianting XIAO ; Xian LIU ; Song CHI
Publication Type:Journal Article
Keywords: Stroke; Anxiety; Tryptophan hydroxylase 2; Single nucleotide polymorphism
From: Chinese Journal of Behavioral Medicine and Brain Science 2013;22(12):1092-1094
CountryChina
Language:Chinese
Abstract: Objective To investigate the association of two functional polymorphisms of tryptophan hydroxylase 2(THP2) gene,rs4570625 and rs4565946,with poststroke anxiety disorders.Methods Totally 112 poststroke anxiety patients and 246 non-anxious stroke controls were included and completed Hamilton Anxiety Rating Scale.DNA was extracted from blood and genotyped for the two polymorphisms of THP2 gene by polymorphism chain reaction.Results The G allele of rs4570625 was associated with the increased risk of poststroke anxiety.Both the GG genotype and G allele were observed to be significantly higher in female case than in control.No significant difference in genotype and allele firequencies of the rs4565946 was found among the groups.Patients with the G-C haplotype had significantly increased the risk of poststroke anxiety compared to controls.Conclusions Our findings suggest that these ftmctional polymorphisms in TPH2 gene may be involved in development of poststroke anxiety.