The receptor for advanced glycation end products and lung development and lung injury
10.3760/cma.j.issn.1673-4408.2013.05.006
- VernacularTitle:晚期糖基化终末产物受体与肺发育及肺损伤
- Author:
Ping JI
;
Min YU
- Publication Type:Journal Article
- Keywords:
Receptor for advanced glycation end;
Lung Injury;
Therapeutic target
- From:
International Journal of Pediatrics
2013;40(5):454-457
- CountryChina
- Language:Chinese
-
Abstract:
The receptor for advanced glycation end product (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules.As a pattern recognition receptor,it can bind with a variety of ligands.The adult lung is unique in which it expresses high amounts of RAGE under normal conditions while other tissues express low amounts normally and up-regulate RAGE during pathologic processes.The lung exhibits high basal level expression of RAGE localised mainly in alveolar type I cells,suggesting a potentially important role for the receptor in epithelial cell proliferation and differentiation and maintaining lung homeostasis.Indeed,disruption of RAGE levels has been implicated in the pathogenesis of a variety of pulmonary disorders such as acute and chronic lung injury.Furthermore,its soluble form sRAGE,as a decoy receptor,has been shown as an important marker of alveolar epithelial type I cell injury.Studies have suggested that RAGE plays an important role in the biology of the lung and may become a therapeutic target for lung injury.
