Effects of Moldavica Total Flavone on Vascular Endothelial Growth Factor, Intercellular Adhesinon Molecule-1 and Other Cytokines in Bronchial Asthmatic Rats
10.3969/j.issn.1005-5304.2013.09.012
- VernacularTitle:香青兰总黄酮对支气管哮喘大鼠血管内皮生长因子和细胞间黏附分子-1的影响
- Author:
Xiaolong KANG
;
Chenghui HE
;
Jianguo XING
;
Lili YAN
- Publication Type:Journal Article
- Keywords:
moldavica total flavone;
bronchial asthma;
vascular endothelial growth factor;
intercellular adhesion molecule-1;
nitric oxide;
endothelin-1;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(9):34-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of moldavica total flavone on vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1 (ICAM-1), nitric oxide (NO) and endothelin-1 (ET-1) in ovalbumin-induced bronchial asthmatic rats, and explore its mechanism. Methods A total of 60 SD rats was randomly divided into control group, model group, dexamethasone (1 mg/kg) group and moldavica total flavone low (90 mg/kg), medium (180 mg/kg) and high (360 mg/kg) dose group. Rats asthma model was established by ovalbumin challenge methods except the control group. After modeling, rats in control and model groups were intragastrically given distilled water, rats in medicine groups were intragastrically given moldavica total flavone and dexamethasone for 30 d. VEGF in lung tissue and ICAM-1 in bronchoalveolar lavage fluid (BALF) were detected respectively by ELISA. The content of ET-1 and NO in BALF were analyzed with radioimmunity method and nitric acid reductase method. Results The VEGF in lung tissue and ICAM-1, NO and ET-1 in BALF were decreased by moldavica total flavone at 180 and 360 mg/kg (P<0.05, P<0.01) in ovalbumin-induced bronchial asthmatic rats. Conclusion Moldavica total flavone is effective in adjusting abnormal increase of VEGF, ICAM-1, ET-1 and NO of bronchial asthma rats.
