BDNF and TrkB may be new hope for treatment of tumor
10.3760/cma.j.issn.1673-4203.2013.06.010
- VernacularTitle:BDNF及TrKB可能成为肿瘤治疗的新希望
- Author:
Tidong MA
;
Bixiang LI
- Publication Type:Journal Article
- Keywords:
Brain-derived neurotrophic factor;
Receptor,TrkB;
Neoplasms;
Therapy
- From:
International Journal of Surgery
2013;(6):389-394
- CountryChina
- Language:Chinese
-
Abstract:
Brain-derived neurotrophic factor is the ligands of tyrosine kinase receptor B,for the binding of brain-derived neurotrophic factor to tyrosine kinase receptor B receptor,signal transmitted to the nucleus,resulting in a variety of biological effects.Lots of researchs had found that brain-derived neurotrophic factor and tyrosine kinase receptor B expression in malignant tumors more than non-cancerous adjacent tissue and normal tissue,and their effect can promote tumor blood vessel formation,suppress of cell anoikis,promote tumor growth,differentiation and metastasis.The relationship of brain-derived neurotrophic factor and tyrosine kinase receptor B provide a new therapeutic strategy for clinical treatment.From the current basic and clinical research,this treatment strategy has great prospect.
