The significance of peripheral zone imaging features on pelvic T2 weighted imaging for the diagnosis of prostate cancer with PSA ＜ 20 μg/L
10.3760/cma.j.issn.1000-6702.2013.04.017
- VernacularTitle:盆腔磁共振T2加权像前列腺外周带影像特征对PSA＜20 μg/L前列腺癌诊断的意义
- Author:
Xuan WANG
;
Ming LIU
;
Min CHEN
;
Chunmei LI
;
Ben WAN
;
Dong WEI
;
Jianye WANG
- Publication Type:Journal Article
- Keywords:
Prostate cancer;
Early diagnosis;
Magnetic resonance imaging (MRI);
Retrospective study
- From:
Chinese Journal of Urology
2013;(4):292-297
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of 1.5-Tesla MRI in the early diagnosis of prostate cancer,and analyze the imaging features in T2WI which are helpful for the diagnosis on early prostate cancer.Methods The clinical data of patients with PSA ＜ 20 μg/L who received prostate biopsy between Feb.2006 and Jan.2011 were reviewed including pelvic MRI and biopsy results.We retrospectively analyzed T2WI image features and evaluated the signal of peripheral zone,seminal vesicles,prostate capsule and the relationship with their surrounding tissues.The results of the reading were analyzed with reference to histopathologic evaluation of prostate biopies.Results Among 359 patients,137 patients were diagnosed prostate cancer and 332 cases were found with low signal lesions on peripheral zone of T2WI.Univariate logistic regression analysis showed that age and PSA are closely related to the diagnosis of prostate cancer (P ＜ 0.05).Low signal lesions on peripheral zone of T2WI are more helpful for the diagnosis of prostate cancer on the image.Number,shape,margin of lesions,the contour of the prostatic capsule,the boundary of peripheral zone and transitional zone are significantly associated with the diagnosis of prostate cancer.Through multivariate logistic regression analysis,it was found that age (P ＜ 0.05),PSA (P ＜ 0.05),prostate volume (P ＜ 0.05),lesion shape (flaky vs nodular,P ＜ 0.05 ; diffuse vs nodular,P ＜ 0.05) and the contour of the prostatic capsule (disappearing vs completely clear,P ＜ 0.05) are risk factors of prostate cancer.The areas under receiver operating characteristic curve are 0.833 (P ＜ 0.05).Conclusions In T2WI,lesion shape and the contour of the prostatic capsule are risk factors of prostate cancer.Age,PSA,prostate volume are also significantly associated with the diagnosis of prostate cancer.
